DOI: 10.1002/ame2.12008
Overview of the reporter genes and reporter mouse models
Shun Li
Li-xiang Chen
Xiu-hua Peng
Chao Wang
Bo-yin Qin
Dan Tan
Cheng-xiao Han
Hua Yang
Xiao-nan Ren
Fang Liu
Chun-hua Xu
Xiao-hui Zhou
摘要：Reporter genes are widely applied in biotechnology and biomedical research owning to their easy observation and lack of toxicity. Taking advantage of the reporter genes in conjunction with imaging technologies, a large number of reporter mouse models have been generated. Reporter mouse models provide systems that enable the studies of live cell imaging, cell lineage tracing, immunological research and cancers etc. in vivo. In this review, we describe the types of different reporter genes and reporter mouse models including, random reporter strains, Cre reporter strains and ROSA26 reporter strains. Collectively, these reporter mouse models have broadened scientific inquires and provided potential strategies for generation of novel reporter animal models with enhanced capabilities.
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论文发表日期：2018-01-01
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：7( 29-35 )
英文信息