DOI: 10.1002/ame2.12005
Evaluation of an ischemic model in ischemia prone and general Mongolian gerbils by neurological symptom, injury, and sex difference
Xiao-yan Du
Chang-long Li
Meng Guo
Ying Wang
Hong-gang Guo
Fang-wei Dai
Xiao-ying Sa
Zhen-wen Chen
摘要：Background: In the previous study, we established an ischemia-prone gerbil population (IG), which was selectively bred to increase the incidence of unilateral carotid arterial occlusion (UCO)-induced ischemia in Mongolian gerbils. However, if the characteristics of ischemia model in IG are the same as those in general gerbils (GG), and if the neuro-logical symptoms are associated with the neurological insults in IG is still unclear. Methods: In the present study, we evaluated the UCO model in IG by analyzing neurological symptoms, neurological injury in the hippocampal CA1 region and compared with GG. Results: The data showed that the ratios of neurological symptom scores ≥ 2 in the IG and GG groups were 65.0％ vs 30.0％, respectively, and were significantly differ-ent (P < .01).The neuronal damage following a UCO ischemic insult in the IG group was more severe compared to the GG group. There was a high correlation between the neurological insults' scale and the neurological symptom score in the IG and GG groups (r = .979 and .943 in the IG and GG groups, respectively). In animals with mild neurological symptom scores (2 and 3), the neuronal insults were significantly different between female and male gerbils in both IG and GG. Conclusion: Our findings suggest that IG population would likely be more advantageous to establish an ischemic model.
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论文发表日期：2018-01-01
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：6( 62-67 )
英文信息