DOI: 10.1002/ame2.12032
Enhancer and super-enhancer:Positive regulators in gene transcription
Yanling Peng
Yubo Zhang
摘要：Enhancer is a positive regulator for spatiotemporal development in eukaryotes. As a cluster, super-enhancer is closely related to cell identity- and fate-determined pro-cesses. Both of them function tightly depending on their targeted transcription fac-tors, cofactors, and genes through distal genomic interactions. They have been recognized as critical components and played positive roles in transcriptional regula-tory network or factory. Recent advances of next-generation sequencing have dra-matically expanded our ability and knowledge to interrogate the molecular mechanism of enhancer and super-enhancer for transcription. Here, we review the history, importance, advances and challenges on enhancer and super-enhancer field. This will benefit our understanding of their function mechanism for transcription underlying precise gene expression.
机标关键词：
论文发表日期：2018-01-01
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：11( 169-179 )
英文信息