DOI: 10.1002/ame2.12039
Anti-leukemic and anti-angiogenic effects of D-Limonene on K562-implanted C57BL/6 mice and the chick chorioallantoic membrane model
Bhavini B.Shah
Ruma Baksi
Kiranj K.Chaudagar
Manish Nivsarkar
Anita A.Mehta
摘要：Background:D-Limonene,a monoterpene from citrus fruit has been found to have chemopreventive and chemotherapeutic activities in various types of cancers.In this study,we evaluated the in vivo effect of D-Limonene on a K562-induced model of chronic myeloid leukemia (CML) in C57BL/6 mice.Method:The tail vein injection model of K562 cells in immunocompromised C57BL/6 mice was developed and evaluated for characteristics of the disease.The mice were treated with D-Limonene and evaluated for haematological parameters.We also evaluated the effect of D-Limonene on angiogenesis using the chick chorioallantoic membrane (CAM) assay.Results:In a complete blood count,a significant dose-dependent reduction in white blood cell,neutrophil and lymphocyte counts,but an elevation in red blood cell count and haemoglobin content was observed with D-Limonene treatment compared to the disease control or untreated group.In the CAM assay,D-Limonene produced a significant dose-dependent reduction in number of blood vessels in treatment groups compared to the vehicle-treated group.Conclusion:These studies suggest promising anti-leukemic and anti-angiogenic effects of D-Limonene in the treatment of CML.
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资助基金：We express our deep sense of gratitude to B.V.Patel Pharmaceutical Education and Research Development (PERD) Centre for providing facilities and encouragement to conduct this research work.Financial assistance from DST-INSPIRE for a junior research fellowship to Ms.Bhavini B.Shah (IF 140131)
论文发表日期：2018-01-01
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：6( 328-333 )
英文信息