DOI: 10.1002/ame2.12054
Osteocyte viability and bone density in cadmium chloride-induced osteoporosis ameliorated with Pilostigma thonningii stem bark-extracted D-3-O-methy-chiroinositol
Edwin Aihanuwa Uwagie-Ero
Clifford Nwabugwu Abiaezute
Chinaka O.Nwaehujor
Theophilus Okafor Nnaji
Eugene Amienwanlen Odigie
Oyetunde Kazeem Ekeolu
Ohiemi Benjamin Ocheja
摘要：Background:This study examined the ameliorative effect of D-3-O-methyl-chiroinositol,isolated from the stem bark of Piliostigma thonningii,on cadmium chloride-induced osteoporosis in male Wistar rats.Methods:Thirty-six rats were assigned to three treatment groups (n =12).Group A (2 mL distilled water),group B:(2.5 mg/kg b.w.CdCl2) and group C:(2.5 mg/kg b.w.CdCl2 and D-3-O-methyl-chiroinositol 2 mg/kg b.w.).Bone ash,calcium,phosphate,magnesium,and zinc content,as well as bone histological changes were determined at the end of months 1,2,and 3.Results:There were significant differences (P ≤ 0.05) in the weight of the cervical,tibia,and femoral bones in all groups.The serum concentration of CdCl2 was significantly different across the three groups with time.There was significant variation (P ＜ 0.005) in the mean bone ash across groups.The concentration of OH-proline was significantly different (P ＜ 0.0001) across groups.There were significant differences (P ＜ 0.0001) in bone calcium,magnesium,zinc,and phosphorus concentrations.Histology revealed high levels of bone mineralisation in the CdCl2-treated group,indicative of osteoporosis with hypertrophied osteocytes,while the femur of Wistar rats treated with D-3-O-methyl-chiroinositol showed bone trabeculae and viable osteocytes.Conclusion:The study concluded that D-3-O-methyl-chiroinositol extract from Piliostigma thionningii stem bark ameliorated cadmium chloride-induced osteoporosis in male Wistar rats.
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论文发表日期：2019-01-01
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：9( 25-33 )
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