DOI: 10.1002/ame2.12069
Anti-CRISPRs: The natural inhibitors for CRISPR-Cas systems
Fei Zhang
Guoxu Song
Yong Tian
摘要：CRISPR (clustered regularly interspaced short palindromic repeats)-Cas (CRISPR associated protein) systems serve as the adaptive immune system by which prokaryotes defend themselves against phages.It has also been developed into a series of powerful gene-editing tools.As the natural inhibitors of CRISPR-Cas systems,anti-CRISPRs (Acrs) can be used as the "off-switch" for CRISPR-Cas systems to limit the off-target effects caused by Cas9.Since the discovery of CRISPR-Cas systems,much research has focused on the identification,mechanisms and applications of Acrs.In light of the rapid development and scientific significance of this field,this review summarizes the history and research status of Acrs,and considers future applications.
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论文发表日期：2019-01-01
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：7( 69-75 )
英文信息