DOI: 10.1002/ame2.12067
Effect of the hyaluronic acid-poloxamer hydrogel on skin-wound healing: in vitro and in vivo studies
Xiaojuan Li
Aimin Li
Fan Feng
Qiyu Jiang
Huiwei Sun
Yantao Chai
Ruichuang Yang
Zhijie Wang
Jun Hou
Ruisheng Li
摘要：Background:Recent research into skin injury and wound healing has focused mainly on post-trauma hemostasis,infection prevention,dermal regeneration and angiogenesis.However,less attention has been paid to air permeability and moisture loss prevention which also play important roles in injury healing.Methods:In the present work,we prepared a hyaluronic acid-poloxamer (HA-POL) hydrogel and tested the therapeutic effect of the hydrogel on skin-wound healing.Results:The HA-POL hydrogel transformed from sol to gel at 30℃,close to body temperature,and had stable moisturizing properties.HA-POL hydrogel promoted skin-wound healing and increased protein accumulation in the wound area.HA-POL hydrogel allowed greater air permeability than Band-aid,a typical wound covering.Results from transwell assays showed that the HA-POL hydrogel effectively isolated skin-wounds from bacterial invasion.Conclusion:This work demonstrates the advantages of using HA-POL gel materials in the treatment of cutaneous wounds.
机标关键词：
论文发表日期：2019-01-01
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：7( 107-113 )
英文信息