DOI: 10.1002/ame2.12078
Spontaneous pancreatic undifferentiated pleomorphic sarcoma in a laboratory rat: A case report
Petros Ypsilantis
Soultana Meditskou
Maria Lambropoulou
Theodora Papamitsou
Constantinos Simopoulos
摘要：We present a case of spontaneous undifferentiated/unclassified sarcoma, of a ple-omorphic subtype formerly known as malignant fibrous histiocytoma (UPS/MFH), arising from the pancreas of a laboratory rat. The mass was excised after laparotomy from a 6-month-old female laboratory Wistar rat. It presented a giant multilobulated mass of irregular shape, which had arisen from the pancreas and occupied almost the entire peritoneal cavity. Histologically the tumor was characterized by a highly vari-able morphological pattern, with frequent transitions from storiform to pleomorphic areas. An extensive immunohistochemical examination revealed no specific lines of differentiation. Immunohistochemical positivity was observed only to MIB-1 (high Ki-67 proliferation index), vimentin and CD68 antibodies. The diagnosis was compat-ible with UPS/MFH. To the best of our knowledge, the present case is the first report of a spontaneous primary UPS/MFH arising from the pancreas of a laboratory rat.
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论文发表日期：2019-01-01
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：4( 222-225 )
英文信息