DOI: 10.1002/ame2.12092
Current state of research on non-human primate models of Alzheimer's disease
Hong-Wei Li
Ling Zhang
Chuan Qin
NHC Key Laboratory of Human Disease Comparative Medicine, Peking Union Medical College (PUMC), Beijing, China;Key Laboratory of Human Diseases Animal Model, State Administration of Traditional Chinese Medicine, Peking Union Medical College (PUMC), Beijing, China;The Institute of Laboratory Animal Sciences, Chinese Academy of Medical Sciences (CAMS), Peking Union Medical College (PUMC), Beijing, China;Ministry of Health, Comparative Medicine Center, Peking Union Medical College (PUMC), Beijing, China
摘要：With the increasingly serious aging of the global population, dementia has already become a severe clinical challenge on a global scale. Dementia caused by Alzheimer's disease (AD) is the most common form of dementia observed in the elderly, but its pathogenetic mechanism has still not been fully elucidated. Furthermore, no effec-tive treatment strategy has been developed to date, despite considerable efforts. This can be mainly attributed to the paucity of animal models of AD that are suf-ficiently similar to humans. Among the presently established animal models, non-hu-man primates share the closest relationship with humans, and their neural anatomy and neurobiology share highly similar characteristics with those of humans. Thus, there is no doubt that these play an irreplaceable role in AD research. Considering this, the present literature on non-human primate models of AD was reviewed to provide a theoretical basis for future research.
机标关键词：animal modelstheoretical basisfuture researchform of
资助基金：The CAMS Innovation Fund for Medical Science(2016-12M-2-006 and 2016-12M-1-10)2017-1001-07)((Grant/Award number)
论文发表日期：2019-01-01
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：12( 227-238 )
英文信息