DOI: 10.1002/ame2.12093
Long noncoding RNAs in neurodevelopment and Parkinson's disease
Ying Lyu
Lin Bai
Chuan Qin
Institute of Medical Laboratory Animal Science, Chinese Academy of Medical Sciences & Comparative Medical Center, Peking Union Medical College, Beijing, China
摘要：Long noncoding RNAs (lncRNAs) are RNA molecules comprising more than 200 nu-cleotides, which are not translated into proteins. Many studies have shown that lncR-NAs are involved in regulating a variety of biological processes, including immune, cancer, stress, development and differentiation at the transcriptional, epigenetic or post-transcriptional levels. Here, we review the role of lncRNAs in the process of neurodevelopment, neural differentiation, synaptic function, and pathogenesis of Parkinson's disease (PD). These pathomechanisms include protein misfolding and aggregation, disordered protein degradation, mitochondrial dysfunction, oxidative stress, autophagy, apoptosis, and neuroinflammation. This information will provide the basis of lncRNA-based disease diagnosis and drug treatment for PD.
机标关键词：biological processesprotein degradationdisease diagnosisdrug treatment
论文发表日期：2019-01-01
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：13( 239-251 )
英文信息