DOI: 10.1002/ame2.12090
Downregulation of HNRNPK in human cancer cells inhibits lung metastasis
Mengyuan Li
Wenlong Zhang
Xingjiu Yang
Hongfei Liu
Lin Cao
Weisha Li
Le Wang
Guoxin Zhang
Ran Gao
Key Laboratory of Human Disease Comparative Medicine (National Health and Family Planning Commission), The Institute of Laboratory Animal Science, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, P.R. China;Beijing Engineering Research Center for Experimental Animal Models of Human Critical Diseases, Beijing, P.R. China
摘要：Background: Lung cancer frequently occurs in the clinic, leading to poor prognosis and high mortality. Markers for early diagnosis of lung cancer are scarce, and further potential therapeutic targets are also urgently needed. Method: We established a new mouse model in which the specific gene HNRNPK (heterogeneous nuclear ribonucleoprotein K) was downregulated after administra-tion of doxycycline. The lung metastatic nodules were investigated using biolumines-cence imaging, micro-CT, and autopsy quantification. Results: Compared with the short hairpin negative control group, less lung metastatic nodules were formed in the short hairpin RNA group. Conclusion: Downregulation of HNRNPK in cancer cells can inhibit lung metastasis.
机标关键词：lung cancershort hairpin RNAlung metastasispoor prognosisdiagnosis ofmouse model
论文发表日期：2019-01-01
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：6( 291-296 )
英文信息