DOI: 10.1002/ame2.12102
The role of mouse models in colorectal cancer research—The need and the importance of the orthotopic models
Rui C. Oliveira1
Ana Margarida Abrantes2
José Guilherme Tralh?o3
Maria Filomena Botelho2
1.Biophysics Unit, Faculty of Medicine, University of Coimbra, Coimbra, Portugal;Pathology Department, University Hospital (CHUC), Coimbra, Portugal2.Biophysics Unit, Faculty of Medicine, University of Coimbra, Coimbra, Portugal;Centre of Investigation on Environment, Genetics and Oncobiology (CIMAGO), Coimbra, Portugal3.Biophysics Unit, Faculty of Medicine, University of Coimbra, Coimbra, Portugal;Centre of Investigation on Environment, Genetics and Oncobiology (CIMAGO), Coimbra, Portugal;Surgery A Department, Faculty of Medicine, University Hospital (CHUC), Coimbra, Portugal
摘要：Colorectal cancer is a worldwide health burden, with high incidence and mortality, especially in the advanced stages of the disease. Preclinical models are very impor-tant and valuable to discover and validate early and specific biomarkers as well as new therapeutic targets. In order to accomplish that, the animal models must repli-cate the clinical evolution of the disease in all of its phases. In this article, we review the existent mouse models, with their strengths and weaknesses in the replication of human cancer disease progression, with major focus on orthotopic models.
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论文发表日期：2020-03-25
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：8( 1-8 )
英文信息