DOI: 10.1002/ame2.12098
Long-term case study of a Wuzhishan miniature pig with diabetes
Miaomiao Niu1
Yaqian Liu1
Lei Xiang1
Yuqiong Zhao1
Jifang Yuan1
Yunxiao Jia1
Xin Dai1
Hua Chen2
1.Laboratory Animal Center, Chinese PLA General Hospital, Beijing, PR China2.Laboratory Animal Center, Chinese PLA General Hospital, Beijing, PR China;State Key Laboratory of Kidney Diseases, Chinese PLA General Hospital, Beijing, PR China
摘要：Background: Miniature pigs are attractive animal models for exploring diabetes be-cause they are similar to humans in terms of physiological structure and metabolism. However, little is known about the complications of diabetes in pigs.Methods: In this study, a 28-month observation of a Wuzhishan miniature pig with streptozotocin (STZ)-induced (120 mg/kg) diabetes was conducted, to investigate diabetes-related complications and the possibility of self-recovery in miniature pigs. Blood glucose, serum and urinary biochemistry was measured, and histopathologic examinations of eyes, kidney and pancreas were made. Results: During the observation, diabetic complications of eyes and kidney were observed. The eye complications included bilateral cataracts in the 15th month and degeneration of inner retina and microaneurysm in the 28th month. Kidney complications included glomerular mesangial expansion, focal segmental glomeru-lar sclerosis, and renal tubular epithelial degeneration, but no proteinuria was ob-served. By 28 months after the application of STZ, with no treatment given, blood glucose had recovered and the number of pancreatic islet beta-cells had increased significantly. Conclusions: We showed that the STZ-induced diabetes model in miniature pigs could accurately mimic the pathological changes of human diabetes, and that pancreatic islet beta-cell regeneration did occur in an adult miniature pig, providing a new means for exploring diabetic complications and pancreatic islet beta-cell regeneration.
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论文发表日期：2020-03-25
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：10( 22-31 )
英文信息