DOI: 10.1002/ame2.12110
The use of 5-fluorouracil in the prevention of tendon adhesions: A systematic review
Omid Nazifi1
Andrew L. Stuart1
Dariush Nikkhah2
1.Royal Perth Hospital, Perth, WA, Australia2.Locum Consultant Plastic Surgeon, Department of Plastic and Reconstructive Surgery, Royal Free London NHS Foundation Trust, London, UK
摘要：Background: This systematic review aims to study the effectiveness of 5-fluorouracil (5FU) in the reduction of tendon adhesions postsurgical repair.Method: A systematic review was performed involving four databases, Cochrane, PubMed, MEDLINE, and Embase, looking for evidence of at least Level I or Level II (according to NHMRC) in the use of 5FU in tendon repairs in human or animal studies. Results: Across the four databases 546 articles were identified. Of these 12 were identified as relevant, with a further two being excluded after in depth review. Conclusions: Nine of the 10 studies showed that 5FU was effective at reducing ten-don adhesions in their respective animal studies. One of the 10 studies showed no significant change compared to the control group.
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论文发表日期：2020-03-25
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：6( 87-92 )
英文信息