DOI: 10.1002/ame2.12100
Suitability of the woodchuck HCC as a preclinical model for evaluation of intra-arterial therapies
Alexander Y. Kim1
Joseph H. Yacoub1
David H. Field1
Byoung Uk Park2
Bhaskar Kallakury2
Kyle E. Korolowicz3
Stephan Menne3
1.Department of Radiology, Medstar Georgetown University Hospital, Washington, District of Columbia2.Department of Pathology and Laboratory Medicine, Medstar Georgetown University Hospital, Washington, District of Columbia3.Department of Microbiology and Immunology, Georgetown University Medical Center, Washington, District of Columbia
摘要：The most commonly used preclinical models of hepatocellular carcinoma (HCC) are limited for use in testing of intra-arterial therapies such as transarterial chemoem-bolization and radioembolization. Issues encountered with the more commonly used animal models include dissimilarity in their disease development compared with hu-mans and the size of the vasculature which can make intra-arterial therapy testing difficult or impossible. Here we describe the suitability of the woodchuck HCC model for testing of intra-arterial therapies. We describe the techniques for pre-emboliza-tion imaging assessment using CT and MRI, technical tips on performing angiography and embolization, and pathological assessment of treated liver.
机标关键词：
论文发表日期：2020-03-25
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：5( 98-102 )
英文信息