DOI: 10.1002/ame2.12115
Supplements of an aqueous combination of Justicia adhatoda and Ocimum tenuiflorum boost antioxidative effects and
impede hyperlipidemia
Ifrahim Iqbal Chowdhury1
Md.Atiar Rahman1
Mohammad A.Hashem2
M.Mosharef Hossain Bhuiyan3
Dina Hajjar4
Walla Alelwani4
Arwa A.Makki4
Md.Areeful Haque5
Jitbanjong Tangpong6
M.Taher Bin Bakhtiar7
1.Department of Biochemistry and Molecular Biology,University of Chittagong,Chittagong,Bangladesh2.Department of Biochemistry and Biotechnology,University of Science and Technology Chittagong,Chittagong,Bangladesh3.Department of Chemistry,University of Chittagong,Chittagong,Bangladesh4.Department of Biochemistry,College of Science,University of Jeddah,Jeddah,Saudi Arabia5.Department of Pharmacy,International Islamic University Chittagong,Chittagong,Bangladesh6.School of Allied Health Sciences,Walailak University,Nakhon Si Thammarat,Thailand7.Department of Pharmacy,International Islamic University Malaysia,Kuala Lumpur,Malaysia
摘要：Background:Justicia adhatoda and Ocimum tenuiflorum,locally known as bashok and tulsi,are two ethnomedicinally important herbs that have been using as dietary sup-plements for several therapeutic applications.This study evaluated the combined effect of both the herbs as an antioxidative and antihyperlipidemic agent.Methods:Antihyperlipidemic effect was assessed in a high-fat diet-induced hyper-lipidemic model in Wistar albino rats.The rats were treated orally with extracts of bashok (J adhatoda,200 mg/kg bw),tulshi (O tenuiflorum,200 mg/kg bw),and a com-bination of bashok and tulshi (50:50),as well as with a reference drug,atorvastatin (10 mg/kg/day),with or without high-fat diet for 14 days.The antioxidative effect was studied using established in vitro models.The studies were supported by experi-mentally testing the effects of the extracts on membrane stabilization and inhibition of protein denaturation.Results:The results showed that the serum lipid profile was significantly decreased in the different treatment groups,with bashok having the greatest effect.Body weights,total serum protein,LDH,and relative liver and adipose tissue weights were markedly restored towards baseline values,the lowest atherogenic index being achieved with the combined extract.The combination treatment significantly enhanced total phe-nolic content and antioxidative capacity and greatly potentiated membrane stabiliza-tion,but inhibition of protein denaturation was not significantly affected.Conclusion:The data demonstrate that a combination of Justicia adhatoda and Ocimum tenuiflorum could be developed as a food supplement with antioxidative and antihyperlipidemic benefits.
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论文发表日期：2020-06-25
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：12( 140-151 )
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