DOI: 10.1002/ame2.12125
Apolipoprotein E knockout rabbit model of intracranial atherosclerotic disease
Matthew S.Zabriskie1
Chuanzhuo Wang2
Shuping Wang1
Matthew D.Alexander3
1.Department of Radiology and Imaging Sciences,University of Utah,Salt Lake City,UT,USA2.Department of Radiology,Shengjing Hospital of China Medical University,Shenyang,China3.Department of Radiology and Imaging Sciences,University of Utah,Salt Lake City,UT,USA;Department of Neurosurgery,University of Utah,Salt Lake City,UT,USA
摘要：Intracranial atherosclerotic disease (ICAD) is the most common cause of ischemic stroke.Poor understanding of the disease due to limited human data leads to impre-cise treatment.Apolipoprotein E knockout (ApoE-KO) rabbits were compared to an existing model,the Watanabe heritable hyperlipidemic (WHHL) rabbit,and wild-type New Zealand white (NZW) rabbit controls.Intracranial artery samples were assessed on histopathology for the presence of ICAD.Logistic and ordinal regression analyses were performed to assess for disease presence and severity,respectively.Eighteen rabbits and 54 artery segments were analyzed.Univariate logistic analysis confirmed the presence of ICAD in model rabbits (P < .001),while no difference was found between WHHL and ApoE-KO rabbits (P = .178).In multivariate analysis,only clas-sification as a model vs wild-type animal (P < .001) was associated with the presence of ICAD.Univariate ordinal regression analysis demonstrated an association between ICAD severity and model animals (P = .001),with no difference was noted between WHHL and ApoE-KO rabbits (P = .528).In multivariate ordinal regression analysis,only classification as a model retained significance (P < .001).ICAD can be reliably produced in ApoE-KO rabbits,developing the disease comparably to the older WHHL model.Further analysis is warranted to optimize accelerated development of ICAD in ApoE-KO rabbits to more efficiently study this disease.
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论文发表日期：2020-06-25
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：6( 208-213 )
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