DOI: 10.1002/ame2.12134
Impact of host genetics on gut microbiome: Take-home lessons from human and mouse studies
Inbal Cahana
Fuad A.Iraqi
1.Department of Human Microbiology and Immunology, Sackler Faculty of Medicine, Tel-Aviv University, Tel-Aviv, Israel2.Department of Human Microbiology and Immunology, Sackler Faculty of Medicine, Tel-Aviv University, Tel-Aviv, Israel
摘要：The intestinal microbiome has emerged as an important component involved in vari-ous diseases. Therefore, the interest in understanding the factors shaping its com-position is growing. The gut microbiome, often defined as a complex trait, contains diverse components and its properties are determined by a combination of external and internal effects. Although much effort has been invested so far, it is still difficult to evaluate the extent to which human genetics shape the composition of the gut microbiota. However, in mouse studies, where the environmental factors are better controlled, the effect of the genetic background was significant. The purpose of this paper is to provide a current assessment of the role of human host genetics in shap-ing the gut microbiome composition. Despite the inconsistency of the reported re-sults, it can be estimated that the genetic factor affects a portion of the microbiome. However, this effect is currently lower than the initial estimates, and it is difficult to separate the genetic influence from the environmental effect. Additionally, despite the differences between the microbial composition of humans and mice, results from mouse models can strengthen our knowledge of host genetics underlying the human gut microbial variation.
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论文发表日期：2020-09-25
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：8( 229-236 )
英文信息