DOI: 10.1002/ame2.12142
Research progress on the structure and function of endomucin
Guoxin Zhang
Xingjiu Yang
Ran Gao
1.Key Laboratory of Human DiseaseComparative Medicine (National Health and Family Planning Commission),Institute of Laboratory Animal Science,Chinese Academy of Medical Sciences (CAMS) &Comparative Medicine Centre,Peking Union Medical Collage (PUMC),Beijing,PR China2.Key Laboratory of Human DiseaseComparative Medicine (National Health and Family Planning Commission),Institute of Laboratory Animal Science,Chinese Academy of Medical Sciences (CAMS) &Comparative Medicine Centre,Peking Union Medical Collage (PUMC),Beijing,PR China3.Key Laboratory of Human DiseaseComparative Medicine (National Health and Family Planning Commission),Institute of Laboratory Animal Science,Chinese Academy of Medical Sciences (CAMS) &Comparative Medicine Centre,Peking Union Medical Collage (PUMC),Beijing,PR China
摘要：Endomucin is a type I integral membrane glycoprotein, which is expressed in venous and capillary endothelial cells. It consists of 261 amino acids with an extracellular domain that is highly O -glycosylated at serine and threonine residues and has several potential N -glycosylation sites. Endomucin plays an important role in biological pro-cesses such as cell interaction, molecular cell signaling, angiogenesis and cell migra-tion, and in recent years it has also been identified as an anti-adhesion molecule and a marker of endothelial cells. While it has been shown to be involved in a number of physiological and pathological mechanisms, many of its functions remain unknown, and further study is needed. This article reviews research progress on the function of endomucin to date, in order to provide guidance for future studies.
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论文发表日期：2020-12-25
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：5( 325-329 )
英文信息