DOI: 10.1002/ame2.12155
SARS-CoV-2 infection aggravates chronic comorbidities of cardiovascular diseases and diabetes in mice
Yuanwu Ma
Dan Lu
Linlin Bao
Yajin Qu
Jiangning Liu
Xiaolong Qi
Lei Yu
Xu Zhang
Feifei Qi
Qi Lv
Yunpeng Liu
Xudong Shi
Caixian Sun
Jing Li
Jie Wang
Yunlin Han
Kai Gao
Wei Dong
Ning Liu
Shan Gao
Jing Xue
Qiang Wei
Sidan Pan
Hong Gao
Lianfeng Zhang
Chuan Qin
1.Key Laboratory of Human Disease Comparative Medicine,National Health Commission of China (NHC),Institute of Laboratory Animal Science,Peking Union Medicine College,Chinese Academy of Medical Sciences,Beijing,China;Beijing Engineering Research Center for Experimental Animal Models of Human Critical Diseases,Institute of Laboratory Animal Science,Peking Union Medicine College,Chinese Academy of Medi2.Key Laboratory of Human Disease Comparative Medicine,National Health Commission of China (NHC),Institute of Laboratory Animal Science,Peking Union Medicine College,Chinese Academy of Medical Sciences,Beijing,China;Beijing Engineering Research Center for Experimental Animal Models of Human Critical Diseases,Institute of Laboratory Animal Science,Peking Union Medicine College,Chinese Academy of Medi3.Key Laboratory of Human Disease Comparative Medicine,National Health Commission of China (NHC),Institute of Laboratory Animal Science,Peking Union Medicine College,Chinese Academy of Medical Sciences,Beijing,China;Beijing Engineering Research Center for Experimental Animal Models of Human Critical Diseases,Institute of Laboratory Animal Science,Peking Union Medicine College,Chinese Academy of Medi4.Key Laboratory of Human Disease Comparative Medicine,National Health Commission of China (NHC),Institute of Laboratory Animal Science,Peking Union Medicine College,Chinese Academy of Medical Sciences,Beijing,China;Beijing Engineering Research Center for Experimental Animal Models of Human Critical Diseases,Institute of Laboratory Animal Science,Peking Union Medicine College,Chinese Academy of Medi5.Key Laboratory of Human Disease Comparative Medicine,National Health Commission of China (NHC),Institute of Laboratory Animal Science,Peking Union Medicine College,Chinese Academy of Medical Sciences,Beijing,China;Beijing Engineering Research Center for Experimental Animal Models of Human Critical Diseases,Institute of Laboratory Animal Science,Peking Union Medicine College,Chinese Academy of Medi6.Key Laboratory of Human Disease Comparative Medicine,National Health Commission of China (NHC),Institute of Laboratory Animal Science,Peking Union Medicine College,Chinese Academy of Medical Sciences,Beijing,China;Beijing Engineering Research Center for Experimental Animal Models of Human Critical Diseases,Institute of Laboratory Animal Science,Peking Union Medicine College,Chinese Academy of Medi7.Key Laboratory of Human Disease Comparative Medicine,National Health Commission of China (NHC),Institute of Laboratory Animal Science,Peking Union Medicine College,Chinese Academy of Medical Sciences,Beijing,China;Beijing Engineering Research Center for Experimental Animal Models of Human Critical Diseases,Institute of Laboratory Animal Science,Peking Union Medicine College,Chinese Academy of Medi8.Key Laboratory of Human Disease Comparative Medicine,National Health Commission of China (NHC),Institute of Laboratory Animal Science,Peking Union Medicine College,Chinese Academy of Medical Sciences,Beijing,China;Beijing Engineering Research Center for Experimental Animal Models of Human Critical Diseases,Institute of Laboratory Animal Science,Peking Union Medicine College,Chinese Academy of Medi9.Key Laboratory of Human Disease Comparative Medicine,National Health Commission of China (NHC),Institute of Laboratory Animal Science,Peking Union Medicine College,Chinese Academy of Medical Sciences,Beijing,China;Beijing Engineering Research Center for Experimental Animal Models of Human Critical Diseases,Institute of Laboratory Animal Science,Peking Union Medicine College,Chinese Academy of Medi10.Key Laboratory of Human Disease Comparative Medicine,National Health Commission of China (NHC),Institute of Laboratory Animal Science,Peking Union Medicine College,Chinese Academy of Medical Sciences,Beijing,China;Beijing Engineering Research Center for Experimental Animal Models of Human Critical Diseases,Institute of Laboratory Animal Science,Peking Union Medicine College,Chinese Academy of Medi11.Key Laboratory of Human Disease Comparative Medicine,National Health Commission of China (NHC),Institute of Laboratory Animal Science,Peking Union Medicine College,Chinese Academy of Medical Sciences,Beijing,China;Beijing Engineering Research Center for Experimental Animal Models of Human Critical Diseases,Institute of Laboratory Animal Science,Peking Union Medicine College,Chinese Academy of Medi12.Key Laboratory of Human Disease Comparative Medicine,National Health Commission of China (NHC),Institute of Laboratory Animal Science,Peking Union Medicine College,Chinese Academy of Medical Sciences,Beijing,China;Beijing Engineering Research Center for Experimental Animal Models of Human Critical Diseases,Institute of Laboratory Animal Science,Peking Union Medicine College,Chinese Academy of Medi13.Key Laboratory of Human Disease Comparative Medicine,National Health Commission of China (NHC),Institute of Laboratory Animal Science,Peking Union Medicine College,Chinese Academy of Medical Sciences,Beijing,China;Beijing Engineering Research Center for Experimental Animal Models of Human Critical Diseases,Institute of Laboratory Animal Science,Peking Union Medicine College,Chinese Academy of Medi14.Key Laboratory of Human Disease Comparative Medicine,National Health Commission of China (NHC),Institute of Laboratory Animal Science,Peking Union Medicine College,Chinese Academy of Medical Sciences,Beijing,China;Beijing Engineering Research Center for Experimental Animal Models of Human Critical Diseases,Institute of Laboratory Animal Science,Peking Union Medicine College,Chinese Academy of Medi15.Key Laboratory of Human Disease Comparative Medicine,National Health Commission of China (NHC),Institute of Laboratory Animal Science,Peking Union Medicine College,Chinese Academy of Medical Sciences,Beijing,China;Beijing Engineering Research Center for Experimental Animal Models of Human Critical Diseases,Institute of Laboratory Animal Science,Peking Union Medicine College,Chinese Academy of Medi16.Key Laboratory of Human Disease Comparative Medicine,National Health Commission of China (NHC),Institute of Laboratory Animal Science,Peking Union Medicine College,Chinese Academy of Medical Sciences,Beijing,China;Beijing Engineering Research Center for Experimental Animal Models of Human Critical Diseases,Institute of Laboratory Animal Science,Peking Union Medicine College,Chinese Academy of Medi17.Key Laboratory of Human Disease Comparative Medicine,National Health Commission of China (NHC),Institute of Laboratory Animal Science,Peking Union Medicine College,Chinese Academy of Medical Sciences,Beijing,China;Beijing Engineering Research Center for Experimental Animal Models of Human Critical Diseases,Institute of Laboratory Animal Science,Peking Union Medicine College,Chinese Academy of Medi18.Key Laboratory of Human Disease Comparative Medicine,National Health Commission of China (NHC),Institute of Laboratory Animal Science,Peking Union Medicine College,Chinese Academy of Medical Sciences,Beijing,China;Beijing Engineering Research Center for Experimental Animal Models of Human Critical Diseases,Institute of Laboratory Animal Science,Peking Union Medicine College,Chinese Academy of Medi19.Key Laboratory of Human Disease Comparative Medicine,National Health Commission of China (NHC),Institute of Laboratory Animal Science,Peking Union Medicine College,Chinese Academy of Medical Sciences,Beijing,China;Beijing Engineering Research Center for Experimental Animal Models of Human Critical Diseases,Institute of Laboratory Animal Science,Peking Union Medicine College,Chinese Academy of Medi20.Key Laboratory of Human Disease Comparative Medicine,National Health Commission of China (NHC),Institute of Laboratory Animal Science,Peking Union Medicine College,Chinese Academy of Medical Sciences,Beijing,China;Beijing Engineering Research Center for Experimental Animal Models of Human Critical Diseases,Institute of Laboratory Animal Science,Peking Union Medicine College,Chinese Academy of Medi21.Key Laboratory of Human Disease Comparative Medicine,National Health Commission of China (NHC),Institute of Laboratory Animal Science,Peking Union Medicine College,Chinese Academy of Medical Sciences,Beijing,China;Beijing Engineering Research Center for Experimental Animal Models of Human Critical Diseases,Institute of Laboratory Animal Science,Peking Union Medicine College,Chinese Academy of Medi22.Key Laboratory of Human Disease Comparative Medicine,National Health Commission of China (NHC),Institute of Laboratory Animal Science,Peking Union Medicine College,Chinese Academy of Medical Sciences,Beijing,China;Beijing Engineering Research Center for Experimental Animal Models of Human Critical Diseases,Institute of Laboratory Animal Science,Peking Union Medicine College,Chinese Academy of Medi23.Key Laboratory of Human Disease Comparative Medicine,National Health Commission of China (NHC),Institute of Laboratory Animal Science,Peking Union Medicine College,Chinese Academy of Medical Sciences,Beijing,China;Beijing Engineering Research Center for Experimental Animal Models of Human Critical Diseases,Institute of Laboratory Animal Science,Peking Union Medicine College,Chinese Academy of Medi24.Key Laboratory of Human Disease Comparative Medicine,National Health Commission of China (NHC),Institute of Laboratory Animal Science,Peking Union Medicine College,Chinese Academy of Medical Sciences,Beijing,China;Beijing Engineering Research Center for Experimental Animal Models of Human Critical Diseases,Institute of Laboratory Animal Science,Peking Union Medicine College,Chinese Academy of Medi25.Key Laboratory of Human Disease Comparative Medicine,National Health Commission of China (NHC),Institute of Laboratory Animal Science,Peking Union Medicine College,Chinese Academy of Medical Sciences,Beijing,China;Beijing Engineering Research Center for Experimental Animal Models of Human Critical Diseases,Institute of Laboratory Animal Science,Peking Union Medicine College,Chinese Academy of Medi26.Key Laboratory of Human Disease Comparative Medicine,National Health Commission of China (NHC),Institute of Laboratory Animal Science,Peking Union Medicine College,Chinese Academy of Medical Sciences,Beijing,China;Beijing Engineering Research Center for Experimental Animal Models of Human Critical Diseases,Institute of Laboratory Animal Science,Peking Union Medicine College,Chinese Academy of Medi
摘要：Background:Cardiovascular diseases (CVDs) and diabetes mellitus (DM) are top two chronic comorbidities that increase the severity and mortality of COVID- 19. However, how SARS- CoV- 2 alters the progression of chronic diseases remain unclear. Methods:We used adenovirus to deliver h- ACE2 to lung to enable SARS- CoV- 2 infection in mice. SARS- CoV- 2's impacts on pathogenesis of chronic diseases were studied through histopathological, virologic and molecular biology analysis.Results:Pre- existing CVDs resulted in viral invasion, ROS elevation and activation of apoptosis pathways contribute myocardial injury during SARS- CoV- 2 infection. Viral infection increased fasting blood glucose and reduced insulin response in DM model. Bone mineral density decreased shortly after infection, which associated with im-paired PI3K/AKT/mTOR signaling. Conclusion:We established mouse models mimicked the complex pathological symp-toms of COVID- 19 patients with chronic diseases. Pre- existing diseases could impair the inflammatory responses to SARS- CoV- 2 infection, which further aggravated the pre- existing diseases. This work provided valuable information to better understand the interplay between the primary diseases and SARS- CoV- 2 infection.
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论文发表日期：2021-03-25
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：14( 2-15 )
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