DOI: 10.1002/ame2.12143
Tiletamine/zolazepam and dexmedetomidine with tramadol provide effective general anesthesia in rats
Vudhiporn Limprasutr1
Patrick Sharp2
Katechan Jampachaisri3
Cholawat Pacharinsak4
Sumit Durongphongtorn5
1.Department of Pharmacology and Physiology,Faculty of Pharmaceutical Sciences,Chulalongkorn University,Bangkok,Thailand;Research Clusters: Preclinical Toxicity and Efficacy Assessment of Medicines and Chemicals,Chulalongkorn University,Bangkok,Thailand2.Animal Resources Centre,Murdoch,WA,Australia3.Department of Mathematics,Faculty of Sciences,Naresuan University,Phitsanulok,Thailand4.Department of Comparative Medicine,School of Medicine,Stanford University,Stanford,CA,USA5.Department of Veterinary Surgery,Faculty of Veterinary Science,Chulalongkorn University,Bangkok,Thailand
摘要：Background:Tiletamine/zolazepam is a dissociative anesthetic combination com-monly used in small animals but information is limited in rats. The alpha-2 agonist, dexmedetomidine, has gained popularity in laboratory animal anesthesia. Tramadol is a weak opioid mu agonist. The aim of this study was to assess whether the tileta-mine/zolazepam/dexmedetomidine (ZD) combination effectively provides a surgical anesthesia plane comparable to tiletamine/zolazepam/dexmedetomidine with tram-adol (ZDT) in a minor procedure in rats. Methods:Rats were induced with ZD or ZDT. After the loss of paw withdrawal, a small incision was made on the rats' left thighs as a surgical stimulus. Rats were main-tained under a surgical anesthesia plane by assessing the loss of the paw withdrawal reflex for 45 minutes, then atipamezole was administered. Monitored anesthesia parameters included: (a) physiological parameters - pulse rate (PR), respiratory rate (RR), tissue oxygen saturation (％SpO 2 ), and body temperature; (b) duration param-eters - induction time, onset and duration of surgical anesthesia plane, onset of re-covery, and recovery time. Results:PR was significantly lower at 10 minutes in ZD and 5 minutes in ZDT groups. No difference was observed for RR, ％SpO 2 , and body temperature. Likewise, there were no differences for duration parameters: induction time was less than 3 minutes; onset and duration of surgical anesthesia plane were approximately 5 and 45 min-utes, respectively; onset of recovery (time to move) was 51 minutes; and recovery time was 52 minutes, respectively. Conclusion:These data suggest the ZD combination provides a surgical anesthesia plane comparable to ZDT in a rat incisional pain model.
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论文发表日期：2021-03-25
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：7( 40-46 )
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