Radiation-induced oral mucositis hamster model using a linear accelerator enhances clinical relevance of preclinical studies for treatment strategy investigation

Carolyn T.Jordan; Emily M.Bradford; Dennis C.Cheek; Mahesh Kudrimoti; Craig S.Miller; Molly H.Smith; J.Zach Hilt; Thomas D.Dziubla

doi:10.1002/ame2.12148

首页>文献>Radiation-induced oral mucositis hamster model using a linear accelerator enhances clinical relevance of preclinical studies for treatment strategy investigation

DOI: 10.1002/ame2.12148

Radiation-induced oral mucositis hamster model using a linear accelerator enhances clinical relevance of preclinical studies for treatment strategy investigation

Carolyn T.Jordan¹

Emily M.Bradford²

Dennis C.Cheek³

Mahesh Kudrimoti³

Craig S.Miller⁴

Molly H.Smith⁵

J.Zach Hilt¹

Thomas D.Dziubla¹

1.Department of Chemical and Materials Engineering,University of Kentucky,Lexington,KY,USA2.Department of Internal Medicine,University of Kentucky,Lexington,KY,USA3.Department of Radiation Medicine,University of Kentucky,Lexington,KY,USA4.Department of Oral Health Practice,University of Kentucky,Lexington,KY,USA5.Department of Oral and Maxillofacial Pathology,University of Kentucky,Lexington,KY,USA

摘要：Translational animal models for oral mucositis (OM) are necessary to simulate and assess the bioclinical effects and response in humans. These models should simulate high levels of radiation exposure that leads to oxidative stress and inflammatory-initiated tissue changes. Hamster models have been extensively studied to observe pathological effects of radiation exposure and help in the development of effective treatments. To successfully evaluate the potential for treatment regimens with con-sistency and relevance, a radiation-induced OM hamster model was developed using a clinical linear accelerator utilized by cancer patients daily. The dose exposure to the isolated, everted cheek pouch of a hamster, as well as the progression of injury, pro-inflammatory marker, histological, and elasticity analyses of the buccal pouch were conducted to verify replicability and reproducibility of the injury model. The findings from this model demonstrated its ability to consistently induce injury and resolution over 28 days using an acute dose of 60 Gy. This model was developed to enhance clinical relevance when evaluating potential efficacious treatments and can now be utilized in efficacy studies to better evaluate developed therapeutics in a preclinical model that is easy to translate to clinical studies..

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论文发表日期：2021-03-25

在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）

页数：7( 47-53 )

英文信息展开

动物模型与实验医学（英文）

ISSN：2096-5451

年,卷(期)：2021,4(1)

所属栏目：Short Communication