DOI: 10.1002/ame2.12149
Innovations in osteomyelitis research: A review of animal models
Kylie M.Roux1
Leah H.Cobb2
Marc A.Seitz1
Lauren B.Priddy2
1.College of Veterinary Medicine,Mississippi State University,Mississippi State,MS,USA2.Department of Agricultural and Biological Engineering,Mississippi State University ,Mississippi State,MS,USA
摘要：Infection of bone tissue, or osteomyelitis, has become a growing concern in modern healthcare due in no small part to a rise in antibiotic resistance among bacteria, no-tably Staphylococcus aureus . The current standard of care involves aggressive, pro-longed antibiotic therapy combined with surgical debridement of infected tissues. While this treatment may be sufficient for resolving a portion of cases, recurrences of the infection and associated risks including toxicity with long-term antibiotic usage have been reported. Therefore, there exists a need to produce safer, more effica-cious options of treatment for osteomyelitis. In order to test treatment regimens, ani-mal models that closely mimic the clinical condition and allow for accurate evaluation of therapeutics are necessary. Establishing a model that replicates features of osteo-myelitis in humans continues to be a challenge to scientists, as there are many vari-ables involved, including choosing an appropriate species and method to establish infection. This review addresses the refinement of animal models of osteomyelitis to reflect the clinical disease and test prospective therapeutics. The aim of this review is to explore studies regarding the use of animals for osteomyelitis therapeutics re-search and encourage further development of such animal models for the translation of results from the animal experiment to human medicine.
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论文发表日期：2021-03-25
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：12( 59-70 )
英文信息