DOI: 10.1002/ame2.12144
Summary of animal models of myelodysplastic syndrome
Weisha Li1
Mengyuan Li1
Xingjiu Yang1
Wenlong Zhang1
Lin Cao2
Ran Gao1
1.NHC Key Laboratory of Human Disease Comparative Medicine,Beijing,China;Beijing Engineering Research Center for Experimental Animal Models of Human Critical Diseases,Beijing,China;Institute of Laboratory Animal Sciences,Chinese Academy of Medical Sciences (CAMS),Beijing,China;Comparative Medicine Center,Peking Union Medical College (PUMC),Beijing,China2.Beijing Tongren Hospital Affiliated to Capital Medical University,Beijing,China
摘要：Myelodysplastic syndrome (MDS) is a malignant tumor of the hematological system characterized by long-term, progressive refractory hemocytopenia. In addition, the risk of leukemia is high, and once it develops, the course of acute leukemia is short with poor curative effect. Animal models are powerful tools for studying human diseases and are highly effective preclinical platforms. Animal models of MDS can accurately show genetic aberrations and hematopoietic clone phenotypes with simi-lar cellular features (such as impaired differentiation and increased apoptosis), and symptoms can be used to assess existing treatments. Animal models are also helpful for understanding the pathogenesis of MDS and its relationship with acute leukemia, which helps with the identification of candidate genes related to the MDS pheno-type. This review summarizes the current status of animal models used to research myelodysplastic syndrome (MDS).
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论文发表日期：2021-03-25
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：6( 71-76 )
英文信息