DOI: 10.1002/ame2.12160
Mesenteric traction syndrome in pigs: A single- blinded, randomized controlled trial
Rune B.Strandby1
Jens T.F.Osterkamp1
Rikard Ambrus1
Amelie Henriksen1
Jens P.Goetze2
Niels H.Secher3
Michael P.Achiam1
Lars-Bo Svendsen1
1.Department of Surgical Gastroenterology,Rigshospitalet,University of Copenhagen,Copenhagen ?,Denmark2.Department of Clinical Biochemistry,Rigshospitalet,University of Copenhagen,Copenhagen ?,Denmark3.Department of Anaesthesia,Rigshospitalet,University of Copenhagen,Copenhagen ?,Denmark
摘要：Background : Mesenteric traction syndrome is commonly observed in patients undergoing upper abdominal surgery and is associated with severe postoperative complications. A triad of hypotension, tachycardia, and facial flushing seems provoked by prostacyclin (PGI 2 ) release from the gut in response to mesenteric traction. The administration of nonsteroidal anti-i nflammatory drugs (NSAID) inhibits PGI 2 release, stabilizing the hemodynamic response. Here, we examined the effect of mesenteric traction on splanchnic blood flow in pigs randomized to NSAID or placebo treatment. Materials and Methods : Twenty pigs were allocated to either ketorolac or pla-cebo treatment. Five minutes of manual mesenteric traction was applied. Plasma 6- keto- PGF1 , a stable metabolite of PGI 2 , hemodynamic variables, and regional blood flow (laser speckle contrast imaging) to the liver, stomach, small intestine, upper lip, and snout (laser Doppler flowmetry) were recorded prior to traction and 5 and 30 minutes thereafter.Results : Both groups of pigs presented a decrease in systemic vascular resistance ( P .01), mean arterial blood pressure ( P .001), and blood flow in the gastric an-trum ( P .002). Plasma 6- keto- PGF1 did not increase in either group ( P .195), and cardiac output, heart rate, central venous pressure, and blood flow to the liver, small intestine, upper lip, and snout remained unchanged. Conclusion : Mesenteric traction resulted in cardiovascular depression, including re-duced blood flow in the gastric antrum. Plasma 6- keto- PGF1 did not increase, and ketorolac administration did not alter the response to mesenteric traction. Furthers studies are needed to identify which substance is responsible for eliciting the cardio-vascular response to mesenteric traction in pigs.
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论文发表日期：2021-06-25
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：7( 162-168 )
英文信息