DOI: 10.1002/ame2.12177
An insight on established retinal injury mechanisms and prevalent retinal stem cell activation pathways in vertebrate models
Rinchen Doma Sherpa
Subhra Prakash Hui
S.N.Pradhan Centre for Neurosciences,University of Calcutta,Kolkata,India
摘要：Implementing different tools and injury mechanisms in multiple animal models of retina regeneration, researchers have discovered the existence of retinal stem/pro-genitor cells. Although they appear to be distributed uniformly across the vertebrate lineage, the reparative potential of the retina is mainly restricted to lower vertebrates. Regenerative repair post- injury requires the creation of a proliferative niche, vital for proper stem cell activation, propagation, and lineage differentiation. This seems to be lacking in mammals. Hence, in this review, we first discuss the many forms of retinal injuries that have been generated using animal models. Next, we discuss how they are utilized to stimulate regeneration and mimic eye disease pathologies. The key to driving stem cell activation in mammals relies on the information we can gather from these models. Lastly, we present a brief update about the genes, growth factors, and signaling pathways that have been brought to light using these models.
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论文发表日期：2021-09-25
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：15( 189-203 )
英文信息