DOI: 10.1002/ame2.12176
Refining murine heterotopic heart transplantation: A model to study ischemia and reperfusion injury in donation after circulatory death hearts
Mohammed Quader1
Renee Cholyway1
Niluka Wickramaratne1
Oluwatoyin Akande1
Martin Mangino1
Eleonora Mezzaroma2
Adolfo G.Mauro3
Qun Chen3
Alexander Kantlis1
Stefano Toldo3
1.Division of Cardiothoracic Surgery,Pauley Heart Center,Virginia Commonwealth University,Richmond,VA,USA2.School of Pharmacy,Virginia Commonwealth University,Richmond,VA,USA3.Division of Cardiology,Pauley Heart Center,Virginia Commonwealth University,Richmond,VA,USA
摘要：Heart transplantation is a lifesaving procedure, which is limited by the availability of donor hearts. Using hearts from donors after circulatory death, which have sustained global ischemia, requires thorough studies on reliable and reproducible models that developing researchers may not have mastered. By combining the most recent lit-erature and our recommendations based on observations and trials and errors, the methods here detail a sound in vivo heterotopic heart transplantation model for rats in which protective interventions on the ischemic heart can be studied, and thus al-lowing the scientific community to advance organ preservation research. Knowledge gathered from reproducible animal models allow for successful translation to clinical studies.
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论文发表日期：2021-09-25
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：14( 283-296 )
英文信息