DOI: 10.1002/ame2.12183
The hypoxia adaptation of small mammals to plateau and underground burrow conditions
Mengke Li1
Dan Pan1
Hong Sun2
Lei Zhang1
Han Cheng1
Tian Shao1
Zhenlong Wang1
1.School of Life Sciences , Zhengzhou University , Zhengzhou , P.R. China2.School of Life Sciences , Zhengzhou University , Zhengzhou , P.R. China;Centre for Nutritional Ecology , Zhengzhou University , Zhengzhou , P.R. China
摘要：Oxygen is one of the important substances for the survival of most life systems on the earth, and plateau and underground burrow systems are two typical hypoxic en-vironments. Small mammals living in hypoxic environments have evolved different adaptation strategies, which include increased oxygen delivery, metabolic regula-tion of physiological responses and other physiological responses that change tis-sue oxygen utilization. Multi- omics predictions have also shown that these animals have evolved different adaptations to extreme environments. In particular, vascu-lar endothelial growth factor (VEGF) and erythropoietin (EPO), which have specific functions in the control of O 2 delivery, have evolved adaptively in small mammals in hypoxic environments. Naked mole- rats and blind mole- rats are typical hypoxic model animals as they have some resistance to cancer. This review primarily summa-rizes the main living environment of hypoxia tolerant small mammals, as well as the changes of phenotype, physiochemical characteristics and gene expression mode of their long- term living in hypoxia environment.
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论文发表日期：2021-12-25
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：10( 319-328 )
英文信息