DOI: 10.1002/ame2.12187
Closed cranial window rodent model for investigating hemodynamic response to elevated intracranial pressure
Matt T.Oberdier1
James F.Antaki1
Alexander Kharlamov2
Stephen C.Jones2
1.Department of Biomedical Engineering,Carnegie Mellon University,Pittsburgh,Pennsylvania,USA2.Department of Anesthesiology,Allegheny-Singer Research Institute,Pittsburgh,Pennsylvania,USA
摘要：Background : Elevated intracranial pressure (ICP) occurs in several physiological and pathological conditions, yet long- term sequellae are not common, which implies that blood flow is preserved above ischemic thresholds.Methods : This pilot study sought to confirm this hypothesis using a closed cranial window model in a rat in which ICP was elevated to 120 mmHg for 12 min, and superficial cortical perfusion was measured by laser Doppler flowmetry and laser speckle flowmetry. Results : Following a transient increase, cortical blood flow decreased to between 25％ and 75％ of baseline. These levels correspond to disrupted metabolism and de-creased protein synthesis but did not exceed thresholds for electrical signaling or membrane integrity. This may partially explain how some episodes of elevated ICP remain benign. Conclusion : The closed cranial window model provides a platform for prospective study of physiologic responses to artificially elevated ICP during neurosurgery to promote hemostasis.
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论文发表日期：2021-12-25
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：7( 391-397 )
英文信息