DOI: 10.1002/ame2.12212
Hippocampal neurogenesis and pro-neurogenic therapies for Alzheimer's disease
Jie Zheng
Department of Pharmacology,Key Laboratory of Basic Pharmacology of Ministry of Education and Joint International Research Laboratory of Ethnomedicine of Ministry of Education,Key Laboratory of Basic Pharmacology of Guizhou Province,Zunyi Medical University,Zunyi,China
摘要：Adult hippocampal neurogenesis (AHN) facilitates hippocampal circuits plasticity and regulates hippocampus- dependent cognition and emotion. However, AHN malfunc-tion has been widely reported in both human and animal models of Alzheimer's disease (AD), the most common form of dementia in the elderly. Pro- neurogenic therapies in-cluding rescuing innate AHN, cell engraftment and glia- neuron reprogramming hold great potential for compensating the neuronal loss and rewiring the degenerated neu-ronal network in AD, but there are still great challenges to be overcome. This review covers recent advances in unraveling the involvement of AHN in AD and highlights the prospect of emerging pro- neurogenic remedies.
机标关键词：
论文发表日期：2022-02-28
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：12( 3-14 )
英文信息