DOI: 10.1002/ame2.12207
Stem cell therapy for Alzheimer's disease: An overview of experimental models and reality
Chuan Qin
Kewei Wang
Ling Zhang
Lin Bai
Institute of Laboratory Animal Sciences,Chinese Academy of Medical Sciences (CAMS),Comparative Medicine Center,Peking Union Medical College(PUMC), NHC Key Laboratory of Human Disease Comparative Medicine,Key Laboratory of Human Diseases Animal Model, Beijing Engineering Research Center for Experimental Animal Models of Human Critical Diseases Beijing,Beijing,China
摘要：Alzheimer's disease (AD) is a neurodegenerative disorder. The pathology of AD is characterized by extracellular amyloid beta (Aβ) plaques, neurofibrillary tangles com-posed of hyperphosphorylated tau, neuronal death, synapse loss, and brain atrophy. Many therapies have been tested to improve or at least effectively modify the course of AD. Meaningful data indicate that the transplantation of stem cells can alleviate neuropathology and significantly ameliorate cognitive deficits in animal models with Alzheimer's disease. Transplanted stem cells have shown their inherent advantages in improving cognitive impairment and memory dysfunction, although certain weak-nesses or limitations need to be overcome. This review recapitulates rodent models for AD, the therapeutic efficacy of stem cells, influencing factors, and the underlying mechanisms behind these changes. Stem cell therapy provides perspective and chal-lenges for its clinical application in the future.
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论文发表日期：2022-02-28
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：12( 15-26 )
英文信息