DOI: 10.1002/ame2.12209
Animal models in the study of Alzheimer's disease and Parkinson's disease: A historical perspective
Rajashree Banerjee
Arushi Rai
Shreyas M.Iyer
Sonia Narwal
Meghana Tare
Department of Biological Sciences,Birla Institute of Technology and Science, Pilani,India
摘要：Alzheimer's disease and Parkinson's disease are two of the most prevalent and disa-bling neurodegenerative diseases globally. Both are proteinopathic conditions and while occasionally inherited, are largely sporadic in nature. Although the advances in our understanding of the two have been significant, they are far from complete and neither diagnosis nor the current practices in treatment and rehabilitation is ad-equately helpful. Animal models have historically found application as testing beds for novel therapeutics and continue to be valuable aids in pharmacological research. This review chronicles the development of those models in the context of Alzheimer's and Parkinson's disease, and highlights the shifting paradigms in studying two human- specific conditions in non- human organisms.
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论文发表日期：2022-02-28
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：11( 27-37 )
英文信息