DOI: 10.1002/ame2.12208
Circular RNAs in pulmonary hypertension: Emerging biological concepts and potential mechanism
Qian Wang1
Yuanyuan Sun2
Qinhua Zhao2
Wenhui Wu2
Lan Wang2
Yuqing Miao3
Ping Yuan2
1.Department of Cardio-Pulmonary Circulation,Shanghai Pulmonary Hospital,School of Medicine,Tongji University, Shanghai,China;Institute of Bismuth Science,University of Shanghai for Science and Technology,Shanghai,China2.Department of Cardio-Pulmonary Circulation,Shanghai Pulmonary Hospital,School of Medicine,Tongji University, Shanghai,China3.Institute of Bismuth Science,University of Shanghai for Science and Technology,Shanghai,China
摘要：Circular RNAs (circRNAs) are endogenous RNAs with a covalently closed single- stranded transcript. They are a novel class of genomic regulators that are linked to many important development and disease processes and are being pursued as clinical and therapeutic targets. Using the most powerful RNA sequencing and bioinformatics techniques, a large number of circRNAs have been identified and further functional studies have been performed. It is known that circRNAs act as potential biomarkers, sponges for microRNAs (miRNAs) and RNA- binding proteins (RBPs), and regulators of mRNA transcription. They also participate in the translation of peptides or proteins. Many types of circRNAs are dysregulated in plasma or lung tissues, and they may be involved in regulating the proliferation and apoptosis of pulmonary artery endothelial cells (PAECs) and pulmonary artery smooth muscle cells (PASMCs), leading to pulmo-nary vascular remodeling in pulmonary hypertension (PH). One possible mechanism is that circRNAs can regulate the function of PAECs and PASMCs by acting as miRNA sponge. However, other potential mechanisms of action of circRNAs are still being actively explored in PH. This paper presents a systematic review of the biogenesis, biological characterization, relevant underlying functions, and future perspectives for studies of circRNAs in the pathogenesis of PH.
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论文发表日期：2022-02-28
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：10( 38-47 )
英文信息