DOI: 10.1002/ame2.12200
A comprehensive neuromonitoring approach in a large animal model of cardiac arrest
Filippo Annoni1
Lorenzo Peluso1
Lucas Akira Hirai2
Giovanni Babini3
Amina Khaldi1
Antoine Herpain1
Lorenzo Pitisci1
Lorenzo Ferlini1
Bruno Garcia1
Fabio Silvio Taccone1
Jacques Creteur1
Fuhong Su1
1.Intensive Care Experimental Laboratory,Intensive Care Unit,Erasme Hospital, Brussel,Belgium2.Intensive Care Unit,S?o Domingos Hospital,S?o Luís,Brazil3.Department of Pathophysiology and Transplants,University of Milan,Milan, Italy;Department of Anesthesiology,Intensive Care and Emergency Fondazione IRCCS Ca'Granda Ospedale Maggiore Policlinico,Milan,Italy
摘要：Background : Anoxic brain injuries represent the main determinant of poor outcome after cardiac arrest (CA). Large animal models have been described to investigate new treatments during CA and post- resuscitation phase, but a detailed model that includes extensive neuromonitoring is lacking. Method : Before an electrically-i nduced 10- minute CA and resuscitation, 46 adult pigs underwent neurosurgery for placement of a multifunctional probe (intracranial pres-sure or ICP, tissue oxygen tension or PbtO 2 and cerebral temperature) and a bolt- based technique for the placement and securing of a regional blood flow probe and two sEEG electrodes; two modified cerebral microdialysis (CMD) probes were also inserted in the frontal lobes and accidental misplacement was prevented using a per-forated head support. Result : 42 animals underwent the CA procedure and 41 achieved the return of spon-taneous circulation (ROSC). In 4 cases (8.6％) an adverse event took place during prep-aration, but only in two cases (4.3％) this was related to the neurosurgery. In 6 animals (13.3％) the minor complications that occurred resolved after probe repositioning. Conclusion : Herein we provide a detailed comprehensive neuromonitoring approach in a large animal model of CA that might help future research.
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论文发表日期：2022-02-28
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：5( 56-60 )
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