DOI: 10.1002/ame2.12216
Sequentially immune-induced antibodies could cross-neutralize SARS-CoV-2 variants
Qi Lv
Shasha Zhou
Feifei Qi
Yaqing Zhang
Fengdi Li
Mingya Liu
Linlin Bao
Beijing Key Laboratory for Animal Models of Emerging and Reemerging Infectious Diseases,NHC Key Laboratory of Human Disease Comparative Medicine,Institute of Laboratory Animal Science,Chinese Academy of Medical Sciences and Comparative Medicine Center,Peking Union Medical College,Beijing,China;National Center of Technology Innovation for Animal Model,Beijing, China
摘要：Background : The Omicron (B.1.1.529) SARS- COV- 2 variant has raised serious con-cerns because of its unprecedented rapid rate of spreading and the fact that there are 36 mutations in the spike protein. Since the vaccine-i nduced neutralizing antibody targets are the spike protein, this may lead to the possibility of vaccine-i nduced hu-moral immunity escape.Methods : We measured the neutralizing activity in vitro for Omicron and compared this with wild type (WH- 09) and Delta variants in human and monkey sera from dif-ferent types of immunity. The monkey sera samples were collected at 1 and 3 months post three- dose inactivated (PiCoVacc) and recombinant protein (ZF2001) vaccination. Human sera were collected from 1 month post three- dose inactivated vaccination. Results : In inactivated vaccine sera, at 1/3 months post three- dose, geometric mean titers (GMTs) of neutralization antibody (NAb) against the Omicron variant were 4.9/5.2- fold lower than those of the wild type. In recombinant protein vaccine sera, GMTs of NAb against Omicron were 15.7/8.9- fold lower than those of the wild type. In human sera, at 1 month post three- dose inactivated vaccination, GMTs of NAb against Omicron were 3.1- fold lower than those of the wild type. Conclusion : This study demonstrated that despite a reduction in neutralization titers, cross- neutralizing activity against Omicron and Delta variants was still observed after three doses of inactivated and recombinant protein vaccination.
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论文发表日期：2022-02-28
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：5( 89-93 )
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