DOI: 10.1002/ame2.12201
Chinese medicine in the treatment of autoimmune hepatitis: Progress and future opportunities
Jia Liu
Zhi Ma
Han Li
Xiaojiaoyang Li
School of Life Sciences,Beijing University of Chinese Medicine,Beijing,China
摘要：Autoimmune hepatitis (AIH) is a chronic inflammatory liver disease occurring in indi-viduals of all ages with a higher incidence in females and characterized by hypergam-maglobulinemia, elevated serum autoantibodies and histological features of interface hepatitis. AIH pathogenesis remains obscure and still needs in- depth study, which is likely associated with genetic susceptibility and the loss of immune homeostasis. Steroids alone and in combination with other immunosuppressant agents are the pri-mary choices of AIH treatment in the clinic, whereas, in some cases, severe adverse effects and disease relapse may occur. Chinese medicine used for the treatment of AIH has proven its merits over many years and is well tolerated. To better under-stand the pathogenesis of AIH and to evaluate the efficacy of novel therapies, several animal models have been generated to recapitulate the immune microenvironment of patients with AIH. In the current review, we summarize recent advances in the study of animal models for AIH and their application in pharmacological research of Chinese medicine- based therapies and also discuss current limitations. This review aims to provide novel insights into the discovery of Chinese medicine- originated therapies for AIH using cutting- edge animal models.
机标关键词：medicinechinesefutureautoimmunehepatitisopportunitiesprogresstreatment
论文发表日期：2022-04-28
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：13( 95-107 )
英文信息