DOI: 10.1002/ame2.12213
Spinal fixation after laminectomy in pigs prevents postoperative spinal cord injur y
Emma M.H.Slot1
Bart de Boer2
Saskia Redegeld3
Sander van Thoor3
Nizar Moayeri1
Willem-Bart Slooff1
Irene A.Schaafsma4
Bj?rn Meij4
Tristan P.C.van Doormaal5
1.Department of Neurology and Neurosurgery,University Medical Center Utrecht,Utrecht,The Netherlands2.Department of Neurosurgery,Elizabeth TweeSteden Hospital,Tilburg,The Netherlands3.Brain Technology Institute,Utrecht,The Netherlands4.Department of Clinical Sciences,Faculty of Veterinary Medicine , Utrecht University , Utrecht , The Netherlands5.Department of Neurology and Neurosurgery,University Medical Center Utrecht,Utrecht,The Netherlands;Department of Neurology and Neurosurgery,University Medical Center Utrecht,Utrecht,The Netherlands
摘要：Background : A safe, effective, and ethically sound animal model is essential for pre-clinical research to investigate spinal medical devices. We report the initial failure of a porcine spinal survival model and a potential solution by fixating the spine.Methods : Eleven female Dutch Landrace pigs underwent a spinal lumbar interlaminar de-compression with durotomy and were randomized for implantation of a medical device or control group. Magnetic resonance imaging (MRI) was performed before termination. Results : Neurological deficits were observed in 6 out of the first 8 animals. Three of these animals were terminated prematurely because they reached the predefined humane endpoint. Spinal cord compression and myelopathy was observed on postop-erative MRI imaging. We hypothesized postoperative spinal instability with epidural hematoma, inherent to the biology of the model, and subsequent spinal cord injury as a potential cause. In the subsequent 3 animals, we fixated the spine with Lubra plates. All these animals recovered without neurological deficits. The extent of spinal cord compression on MRI was variable across animals and did not seem to correspond well with neurological outcome. Conclusion : This study shows that in a porcine i n vivo model of interlaminar decom-pression and durotomy, fixation of the spine after lumbar interlaminar decompression is feasible and may improve neurological outcomes. Additional research is necessary to evaluate this hypothesis.
机标关键词：cordafterpigsfixationinjurlaminectomypostoperativeprevents
论文发表日期：2022-04-28
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：8( 153-160 )
英文信息