DOI: 10.1002/ame2.12198
Anesthesia protocol for ear surgery in Wistar rats (animal research)
Abhijeet Bhatia1
Pranjal Pratim Saikia2
Barilin Dkhar1
Haphidasara Pyngrope1
1.Department of ENT,North Eastern Indira Gandhi Regional Institute of Health&Medical Sciences(NEIGRIHMS),Shillong,India2.Department of Pharmacology(Animal House),North Eastern Indira Gandhi Regional Institute of Health&Medical Sciences(NEIGRIHMS),Shillong,India
摘要：Objective : To formulate an anesthesia protocol for safe and satisfactory anesthesia for ear surgery in rats. Methods : The rats were anesthetized with xylazine (10 mg/kg body weight) and keta-mine at doses of 80, 50, 40, and 30 mg/kg body weight or with isoflurane anesthesia (2％– 3.5％ in 100％ oxygen; maintenance dose 1.5％– 3.5％). The anesthesia induction, surgery, and recovery time were recorded. Results : In total, 17 rats were induced by varying doses of ketamine- xylazine and 28 rats with isoflurane. Mean induction time with ketamine- xylazine was 6 ± 2.9 min compared with 3.8 ± 1.1 min with isoflurane. Mean recovery time with ketamine- xylazine was 142.6 ± 49.3 min compared with 4.1 ± 1.2 min with isoflurane. A mortal-ity of 4 animals after developing dyspnea was recorded with ketamine- xylazine. Conclusion : Isoflurane anesthesia offers appropriate induction and recovery times and low mortality rates for the surgeries performed. Isoflurane anesthesia offers reli-able results for ear surgery in rats. However, more equipment and technical skills are needed.
机标关键词：researchwistarprotocolsurgeryratsanesthesiaanimal
论文发表日期：2022-04-28
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：6( 183-188 )
英文信息