DOI: 10.1002/ame2.12214
Animal models of pulmonary hypertension due to left heart disease
Shao-Fei Liu1
Yi Yan2
1.Charité—Universit?tsmedizin Berlin, Corporate Member of Freie Universit?t Berlin,Humboldt-Universit?t zu Berlin, and Berlin Institute of Health,Berlin, Germany;DZHK(German Centre for Cardiovascular Research),Partner Site Berlin,Berlin, Germany2.Institute for Cardiovascular Prevention (IPEK),Ludwig-Maximilians-University Munich,Munich,Germany;DZHK(German Centre for Cardiovascular Research),Partner Site Munich Heart Alliance,Munich,Germany
摘要：Pulmonary hypertension due to left heart disease (PH- LHD) is regarded as the most prevalent form of pulmonary hypertension (PH). Indeed, PH is an independent risk factor and predicts adverse prognosis for patients with left heart disease (LHD). Clinically, there are no drugs or treatments that directly address PH- LHD, and treat-ment of LHD alone will not also ameliorate PH. To target the underlying physiopatho-logical alterations of PH- LHD and to develop novel therapeutic approaches for this population, animal models that simulate the pathophysiology of PH- LHD are required. There are several available models for PH- LHD that have been successfully employed in rodents or large animals by artificially provoking an elevated pressure load on the left heart, which by transduction elicits an escalated pressure in pulmonary artery. In addition, metabolic derangement combined with aortic banding or vascular en-dothelial growth factor receptor antagonist is also currently applied to reproduce the phenotype of PH- LHD. As of today, none of the animal models exactly recapitulates the condition of patients with PH- LHD. Nevertheless, the selection of an appropriate animal model is essential in basic and translational studies of PH- LHD. Therefore, this review will summarize the characteristics of each PH- LHD animal model and discuss the advantages and limitations of the different models.
机标关键词：hypertensionmodelsheartanimaldiseaseleftpulmonary
论文发表日期：2022-06-28
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：10( 197-206 )
英文信息