DOI: 10.1002/ame2.12220
Experimental animal models of pulmonary hypertension: Development and challenges
Xiao-Han Wu1
Jie-Ling Ma1
Dong Ding2
Yue-Jiao Ma2
Yun-Peng Wei1
Zhi-Cheng Jing1
1.Department of Cardiology,State Key Laboratory of Complex Severe and Rare Diseases,Peking Union Medical College Hospital,Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing,China2.Medical Science Research Center,State Key Laboratory of Complex Severe and Rare Diseases,Peking Union Medical College Hospital,Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing,China
摘要：Pulmonary hypertension (PH) is clinically divided into 5 major types, characterized by elevation in pulmonary arterial pressure (PAP) and pulmonary vascular resistance (PVR), finally leading to right heart failure and death. The pathogenesis of this arte-riopathy remains unclear, leaving it impossible to target pulmonary vascular remod-eling and reverse the deterioration of right ventricular (RV) function. Different animal models have been designed to reflect the complex mechanistic origins and pathology of PH, roughly divided into 4 categories according to the modeling methods: non- invasive models in vivo, invasive models in vivo, gene editing models, and multi- means joint modeling. Though each model shares some molecular and pathological changes with different classes of human PH, in most cases the molecular etiology of human PH is poorly known. The appropriate use of classic and novel PH animal models is es-sential for the hunt of molecular targets to reverse severe phenotypes.
机标关键词：hypertensiondevelopmentmodelsanimalchallengesexperimentalpulmonary
论文发表日期：2022-06-28
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：10( 207-216 )
英文信息