DOI: 10.1002/ame2.12252
Distinct neuronal excitability alterations of medial prefrontal cortex in early- life neglect model of rats
Yu Zhang
Xiuping Sun
Changsong Dou
Xianglei Li
Ling Zhang
Chuan Qin
NHC Key Laboratory of Human Disease Comparative Medicine,Institute of Laboratory Animal Sciences,Chinese Academy of Medical Sciences(CAMS), Comparative Medicine Center,Peking Union Medical College(PUMC),Beijing,China;National Human Diseases Animal Model Resource Center,Beijing,China;Beijing Engineering Research Center for Experimental Animal Models of Human Critical Diseases,Beijing,China;International Center for Technology and Innovation of animal model,Beijing,China;Changping National laboratory(CPNL),Beijing,China
摘要：Object : Early-l ife neglect has irreversible emotional effects on the central nervous system. In this work, we aimed to elucidate distinct functional neural changes in me-dial prefrontal cortex (mPFC) of model rats. Methods : Maternal separation with early weaning was used as a rat model of early- life neglect. The excitation of glutamatergic and GABAergic neurons in rat mPFC was recorded and analyzed by whole- cell patch clamp. Results : Glutamatergic and GABAergic neurons of mPFC were distinguished by typi-cal electrophysiological properties. The excitation of mPFC glutamatergic neurons was significantly increased in male groups, while the excitation of mPFC GABAergic neurons was significant in both female and male groups, but mainly in terms of rest membrane potential and amplitude, respectively. Conclusions : Glutamatergic and GABAergic neurons in medial prefrontal cortex showed different excitability changes in a rat model of early-l ife neglect, which can contribute to distinct mechanisms for emotional and cognitive manifestations.
机标关键词：cortexlifemodelratsalterationsdistinctearly-excitability
论文发表日期：2022-06-28
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：7( 274-280 )
英文信息