DOI: 10.1002/ame2.12262
Research progress on the relationship between intestinal microecology and intestinal bowel disease
Qianhui Fu
Tianyuan Song
Xiaoqin Ma
Jian Cui
School of Pharmacy,Minzu University of China,Beijing,China;Ministry of Education,Key Laboratory of Ethnomedicine,Minzu University of China,Beijing,China
摘要：Intestinal microecology is the main component of human microecology. Intestinal mi-croecology consists of intestinal microbiota, intestinal epithelial cells, and intestinal mucosal immune system. These components are interdependent and establish a com-plex interaction network that restricts each other. According to the impact on the human body, there are three categories of symbiotic bacteria, opportunistic patho-gens, and pathogenic bacteria. The intestinal microecology participates in digestion and absorption, and material metabolism, and inhibits the growth of pathogenic mi-croorganisms. It also acts as the body' s natural immune barrier, regulates the innate immunity of the intestine, controls the mucosal barrier function, and also participates in the intestinal epithelial cells' physiological activities such as hyperplasia or apopto-sis. When the steady- state balance of the intestinal microecology is disturbed, the ex-isting core intestinal microbiota network changes and leads to obesity, diabetes, and many other diseases, especially irritable bowel syndrome, inflammatory bowel disease (IBD), and colorectal malignancy. Intestinal diseases, including tumors, are particularly closely related to intestinal microecology. This article systematically discusses the re-search progress on the relationship between IBD and intestinal microecology from the pathogenesis, treatment methods of IBD, and the changes in intestinal microbiota.
机标关键词：relationshipresearchbetweenboweldiseaseintestinalmicroecologyprogress
论文发表日期：2022-08-28
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：14( 297-310 )
英文信息