DOI: 10.1002/ame2.12255
Association between intestinal microbiota and inflammatory bowel disease
Yunchang Zhang1
Xuemeng Si2
Ling Yang3
Hui Wang3
Ye Sun4
Ning Liu2
1.Ministry of Agriculture and Rural Affairs,Institute of Feed Research,Chinese Academy of Agricultural Sciences,Beijing,China2.State Key Laboratory of Animal Nutrition,Department of Animal Nutrition and Feed Science,China Agricultural University,Beijing,China;Beijing Advanced Innovation Center for Food Nutrition and Human Health,Department of Nutrition and Health,China Agricultural University,Beijing,China3.Department of Food and Bioengineering,Beijing Vocational College of Agriculture,Beijing,China4.Institute of Medical Laboratory Animal Science,Chinese Academy of Medical Sciences&Comparative Medical Center,Peking Union Medical College,Beijing,China
摘要：Inflammatory bowel disease (IBD), which includes Crohn' s disease (CD) and ulcera-tive colitis (UC), has emerged as a global disease with high incidence, long duration, devastating clinical symptoms, and low curability (relapsing immune response and barrier function defects). Mounting studies have been performed to investigate its pathogenesis to provide an ever- expanding arsenal of therapeutic options, while the precise etiology of IBD is not completely understood yet. Recent advances in high- throughput sequencing methods and animal models have provided new insights into the association between intestinal microbiota and IBD. In general, dysbiosis charac-terized by an imbalanced microbiota has been widely recognized as a pathology of IBD. However, intestinal microbiota alterations represent the cause or result of IBD process remains unclear. Therefore, more evidences are needed to identify the pre-cise role of intestinal microbiota in the pathogenesis of IBD. Herein, this review aims to outline the current knowledge of commonly used, chemically induced, and infec-tious mouse models, gut microbiota alteration and how it contributes to IBD, and dysregulated metabolite production links to IBD pathogenesis.
机标关键词：associationbetweenboweldiseaseinflammatoryintestinalmicrobiota
论文发表日期：2022-08-28
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：12( 311-322 )
英文信息