DOI: 10.1002/ame2.12227
Application of zebrafish in the study of the gut microbiome
Xiaoting Zhong1
Jinglin Li2
Furong Lu2
Jingjing Zhang3
Lianxian Guo4
1.Dongguan Key Laboratory of Environmental Medicine,School of Public Health,Guangdong Medical University,Dongguan,China;Affiliated Hospital of Guangdong Medical University&Key Laboratory of Zebrafish Model for Development and Disease,Guangdong Medical University,Zhanjiang,China2.Dongguan Key Laboratory of Environmental Medicine,School of Public Health,Guangdong Medical University,Dongguan,China3.Affiliated Hospital of Guangdong Medical University&Key Laboratory of Zebrafish Model for Development and Disease,Guangdong Medical University,Zhanjiang,China;The Marine Biomedical Research Institute of Guangdong Zhanjiang,Zhanjiang,China4.Dongguan Key Laboratory of Environmental Medicine,School of Public Health,Guangdong Medical University,Dongguan,China;Dongguan Innovation Institute,Guangdong Medical University,Dongguan,China
摘要：Zebrafish ( Danio rerio ) have attracted much attention over the past decade as a reli-able model for gut microbiome research. Owing to their low cost, strong genetic and development coherence, efficient preparation of germ- free (GF) larvae, availability in high- throughput chemical screening, and fitness for intravital imaging in vivo, ze-brafish have been extensively used to investigate microbiome- host interactions and evaluate the toxicity of environmental pollutants. In this review, the advantages and disadvantages of zebrafish for studying the role of the gut microbiome compared with warm- blooded animal models are first summarized. Then, the roles of zebrafish gut microbiome on host development, metabolic pathways, gut- brain axis, and im-mune disorders and responses are addressed. Furthermore, their applications for the toxicological assessment of aquatic environmental pollutants and exploration of the molecular mechanism of pathogen infections are reviewed. We highlight the great po-tential of the zebrafish model for developing probiotics for xenobiotic detoxification, resistance against bacterial infection, and disease prevention and cure. Overall, the zebrafish model promises a brighter future for gut microbiome research.
机标关键词：applicationstudymicrobiomezebrafish
论文发表日期：2022-08-28
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：14( 323-336 )
英文信息