DOI: 10.1002/ame2.12267
Potential anti neuro- inflammatory effect of BioCen- 128 in animal models of dementia
Nashelly Esquivel1
Yenela García1
Roberto Menéndez2
Teidy E.García2
Ana R.Morales3
Claudio Rodríguez1
1.National Center for Bioproducts (BIOCEN),Bejucal,Cuba2.Center for Neurosciences(CNEURO),Playa,Cuba3.Department of Pharmacology,Institute of Marine Sciences(ICIMAR),Havana,Cuba
摘要：Background : BioCen- 128 is a new active pharmaceutical ingredient composed of a specific bovine thymic fraction of a polypeptide nature. Positive results of similar thy-mus extracts have been shown to be effective in delaying the processes associated with aging, immunosenescence and Alzheimer' s disease (AD), where the inflammation plays an important role. Because of the anti-i nflammatory potential of BioCen- 128, the aim of this study was to evaluate the granuloma model induced by a cotton wool implantation and the model induced by intracerebroventricular (ICV) administration of streptozotocin (STZ). Method : The experiment was carried out using male OF- 1 cenp mice weighing 20 ± 2 g. Results : Mice administered BioCen- 128 in via the IP route at 5, 10 and 20 mg/kg of corporal weigh showed a decrease in the wet and dry weights of the granuloma, pro-viding evidence of a systemic anti-i nflammatory effect. In the ICV model of STZ, the administration of BioCen- 128 improved cognitive function. Conclusion : These responses suggested an anti- neuroinflammatory effect explain-able by the action of thymosin β4 and thymosin alfa proteins. The results suggested that BioCen- 128 could be used in the prevention and treatment of some diseases, for example AD, where neuroinflammation is one of the biological events that take place.
机标关键词：modelsanimalantibiocen-dementiaeffectinflammatoryneuro-
论文发表日期：2022-08-28
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：8( 369-376 )
英文信息