DOI: 10.1002/ame2.12283
Contribution of phylogenetics to understanding the evolution and epidemiology of dengue virus
Xi Yu1
Gong Cheng2
1.Tsinghua-Peking Center for Life Sciences,School of Medicine,Tsinghua University,Beijing,China;Institute of Infectious Diseases,Shenzhen Bay Laboratory,Shenzhen,China;Institute of Pathogenic Organisms,Shenzhen Center for Disease Control and Prevention,Shenzhen,China;School of Life Sciences,Tsinghua University,Beijing,China2.Tsinghua-Peking Center for Life Sciences,School of Medicine,Tsinghua University,Beijing,China;Institute of Infectious Diseases,Shenzhen Bay Laboratory,Shenzhen,China;Institute of Pathogenic Organisms,Shenzhen Center for Disease Control and Prevention,Shenzhen,China
摘要：Dengue virus (DENV) is one of the most important arboviral pathogens in the tropics and subtropics, and nearly one-third of the world's population is at risk of infection. The transmission of DENV involves a sylvatic cycle between nonhuman primates (NHP) and Aedes genus mosquitoes, and an endemic cycle between human hosts and predominantly Aedes aegypti.DENV belongs to the genus Flavivirus of the family Flaviviridae and consists of four antigenically distinct serotypes (DENV-1-4). Phylogenetic analyses of DENV have revealed its origin, epidemiology, and the drivers that determine its molecular evolution in nature. This review discusses how phyloge-netic research has improved our understanding of DENV evolution and how it affects viral ecology and improved our ability to analyze and predict future DENV emergence.
机标关键词：epidemiologyevolutionviruscontributiondenguephylogeneticsunderstanding
论文发表日期：2022-10-28
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：8( 410-417 )
英文信息