DOI: 10.1002/ame2.12261
The effects of inactivated SARS-CoV -2 vaccination andsubsequent infection of pregnant mice on the behaviors of offspring
Kaili Lin
Meixuan Liu
Lu Sun
Hongwei Qiao
Shunyi Wang
Sidan Pan
Hanjun Fu
Jingzhu Wang
Qiang Wei
Hong Gao
Institute of Laboratory Animal Science,Chinese Academy of Medical Sciencesand Comparative Medicine Center,Peking Union Medical College,Beijing,China
摘要：The mass inoculation of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccines to induce herd immunity is one of the most effective measures we can deploy in the fight against coronavirus disease 2019 (COVID-19). Pregnant women are prone to a higher risk of COVID-19, and maternal infection is a risk fac-tor for a range of neurological disorders leading to abnormal behavior in adulthood. However, there are limited clinical data to support whether vaccination or infection post-immunization in pregnant women can affect the behavioral cognition of fetuses in adulthood. In this study, human angiotensin-converting enzyme 2 pregnant mice (F0 generation) were immunized with CoronaVac and then infected with SARS-CoV-2. Subsequently, we analyzed the behavioral cognition of their adult offspring (F1 gen-eration) using the open-field test and Morris water maze test. The adult F1 generation did not exhibit any impairments in spontaneous locomotor activity or spatial refer-ence memory.
机标关键词：sars-covmiceandsubsequentbehaviorseffectsinactivatedinfectionoffspring
论文发表日期：2022-10-28
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：6( 430-435 )
英文信息