DOI: 10.1002/ame2.12230
A review: Systematic research approach on toxicity model of liver and kidney in laboratory animals
Abbasali Abbasnezhad1
Fatemeh Salami2
Reza Mohebbati3
1.Department of Physiology,Faculty of Medicine,Gonabad University of Medical Sciences,Gonabad,Iran2.Department of Physiology,Faculty of Medicine,Mashhad University of Medical Sciences,Mashhad,Iran3.Department of Physiology,Faculty of Medicine,Gonabad University of Medical Sciences,Gonabad,Iran;Applied Biomedical Research Center,Mashhad University of Medical Sciences,Mashhad,Iran
摘要：Therapeutic experiments are commonly performed on laboratory animals to inves-tigate the possible mechanism(s) of action of toxic agents as well as drugs or sub-stances under consideration. The use of toxins in laboratory animal models, including rats, is intended to cause toxicity. This study aimed to investigate different models of hepatotoxicity and nephrotoxicity in laboratory animals to help researchers advance their research goals. The current narrative review used databases such as Medline, Web of Science, Scopus, and Embase and appropriate keywords until June 2021. Nephrotoxicity and hepatotoxicity models derived from some toxic agents such as cisplatin, acetaminophen, doxorubicin, some anticancer drugs, and other materials through various signaling pathways are investigated. To understand the models of renal or hepatotoxicity in laboratory animals, we have provided a list of toxic agents and their toxicity procedures in this review.
机标关键词：researchreviewkidneymodelanimalsapproachlaboratoryliver
论文发表日期：2022-10-28
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：9( 436-444 )
英文信息