DOI: 10.1002/ame2.12233
Regulatory effect of gut microbes on blood pressure
Dong Yan1
Ye Sun2
Xiaoyue Zhou1
Wenhao Si3
Jieyu Liu1
Min Li1
Minna Wu1
1.Xinxiang Key Laboratory of Pathogenic Biology, Department of Pathogenic Biology, School of Basic Medical Sciences , Xinxiang Medical University , Xinxiang , China2.Institute of Medical Laboratory Animal Science, Chinese Academy of Medical Sciences & Comparative Medical Center , Peking Union Medical College , Beijing , China3.Xinxiang Key Laboratory of Pathogenic Biology, Department of Pathogenic Biology, School of Basic Medical Sciences , Xinxiang Medical University , Xinxiang , China;Department of Dermatology , the First Affiliated Hospital of Xinxiang Medical University , Xinxiang , China
摘要：Hypertension is an important global public health issue because of its high morbid-ity as well as the increased risk of other diseases. Recent studies have indicated that the development of hypertension is related to the dysbiosis of the gut microbiota in both animals and humans. In this review, we outline the interaction between gut microbiota and hypertension, including gut microbial changes in hypertension, the effect of microbial dysbiosis on blood pressure (BP), indicators of gut microbial dys-biosis in hypertension, and the microbial genera that affect BP at the taxonomic level. For example, increases in Lactobacillus , Roseburia , Coprococcus , Akkermansia , and Bifidobacterium are associated with reduced BP, while increases in Streptococcus , Blautia , and Prevotella are associated with elevated BP. Furthermore, we describe the potential mechanisms involved in the regulation between gut microbiota and hyper-tension. Finally, we summarize the commonly used treatments of hypertension that are based on gut microbes, including fecal microbiota transfer, probiotics and prebi-otics, antibiotics, and dietary supplements. This review aims to find novel potential genera for improving hypertension and give a direction for future studies on gut mi-crobiota in hypertension.
机标关键词：pressurebloodeffectmicrobesregulatory
论文发表日期：2022-12-28
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：19( 513-531 )
英文信息