DOI: 10.1002/ame2.12236
Advances in the pathogenesis of Rett syndrome using cell models
Sijia Lu
Yongchang Chen
Zhengbo Wang
State Key Laboratory of Primate Biomedical Research, Institute of Primate Translational Medicine , Kunming University of Science and Technology , Kunming , China;Yunnan Key Laboratory of Primate Biomedical Research , Kunming , China
摘要：Rett syndrome (RTT) is a progressive neurodevelopmental disorder that occurs mainly in girls with a range of typical symptoms of autism spectrum disorders. MeCP2 pro-tein loss- of- function in neural lineage cells is the main cause of RTT pathogenicity. As it is still hard to understand the mechanism of RTT on the basis of only clinical pa-tients or animal models, cell models cultured in vitro play indispensable roles . Here we reviewed the research progress in the pathogenesis of RTT at the cellular level, summarized the preclinical- research- related applications, and prospected potential future development.
机标关键词：modelscelladvancespathogenesisrettsyndromeusing
论文发表日期：2022-12-28
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：10( 532-541 )
英文信息